Lupus erythematosus - Lupus Eritematos
☆ În rezultatele Stiftung Warentest din Germania din 2022, satisfacția consumatorilor față de ModelDerm a fost doar puțin mai mică decât în cazul consultațiilor plătite de telemedicină.
Apare ca un eritem ușor violet.
Erupția fluture care apare de obicei pe față.
References
Identificarea și clasificarea cutaneous lupus erythematosus (CLE) ridică provocări de diagnostic, deosebindu-l de systemic lupus erythematosus cu implicarea pielii. Studii recente aruncă lumină asupra factorilor genetici, de mediu și imunologici care stau la baza CLE. Inducerea medicamentelor a apărut în mod specific ca unul dintre cei mai importanți factori declanșatori pentru CLE. Tratamentul implică terapii topice și sistemice, inclusiv medicamente promițătoare precum belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 , cu eficacitate demonstrată în studiile clinice.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Cutaneous lupus erythematosus (CLE) acoperă diverse probleme ale pielii, dintre care unele pot fi legate de probleme de sănătate mai ample. Este clasificat în diferite tipuri, cum ar fi acute CLE (ACLE) , sub-acute CLE (SCLE) , and chronic CLE (CCLE) . CCLE cuprinde discoid lupus erythematosus (DLE) , LE profundus (LEP) , chilblain cutaneous lupus, and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Lupus erythematosus este un grup de boli autoimune care pot afecta diferite părți ale corpului. Unele tipuri, cum ar fi systemic lupus erythematosus (SLE) , afectează mai multe organe, în timp ce altele, cum ar fi cutaneous lupus erythematosus (CLE) , afectează în principal pielea. Clasificăm diferite tipuri de CLE pe baza unui amestec de semne clinice, examinare a țesuturilor și teste de sânge, dar există multe variații între indivizi. Problemele cutanate apar adesea din cauza unor factori precum expunerea la soare, fumatul sau anumite medicamente.
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Cauza lupus eritematos (lupus erythematosus) nu este clară. Printre gemenii identici, dacă unul este afectat, există 24% șanse ca celălalt să fie și el. De asemenea, se crede că hormonii sexuali feminini, lumina soarelui, fumatul, deficiența de vitamina D și anumite infecții cresc riscul.
Tratamentele pot include AINS, corticosteroizi, imunosupresoare, hidroxiclorochină și metotrexat. Deși corticosteroizii sunt eficienți, utilizarea pe termen lung duce la efecte secundare.